AMPK activator 11

CAT: 0804-HY-154973Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-154973Size:1 Each
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
AMPK activator 11 is an AMP-activated protein kinase (AMPK) activator with nanomolelevel antiproliferation activities against several CRCs. AMPK activator 11 selectively inhibits the RKO xenograft growth along by activating AMPK and upregulating oxidative phosphorylation (OXPHOS) (mitochondrial metabolism) and can be used for anti-tumor and metabolic disease research[1].
CAS Number
[2948304-00-3]
UNSPSC
12352005
Target
AMPK; Mitochondrial Metabolism; Oxidative Phosphorylation
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ampk-activator-11.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(CCNC2=NC(C3=C(C4=CC=CC=C4N3)C=O)=NC5=C2C=CC=C5)C=C1
Molecular Formula
C25H20N4O2
Molecular Weight
408.45
References & Citations
[1]Xu YH, et.al. Design and Synthesis of Bouchardatine Derivatives as a Novel AMP-Activated Protein Kinase Activator for the Treatment of Colorectal Cancer. J Med Chem. 2023 Jun 8;66 (11) :7387-7404.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Popular Products