AMPK activator 16

• Description:

  AMPK activator 16 (compound 6) is a AMP-activated protein kinase (AMPK) inhibitor. AMPK activator 16 shows the most efficient interactions with the key residues of AMPK and demonstrates significant activation of AMPK. AMPK activator 16 increases the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) (p-ACC) and phosphorylated raptor (p-raptor), in N2a cells[1].

• UNSPSC:

  12352005

• Target:

  Acetyl-CoA Carboxylase; AMPK

• Related Pathways:

  Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease; Neurological Disease

• Smiles:

  O=S (C1=CC=C (Cl) C=C1) (NC2=CC=C (C (/C=C/C3=CC (OC) =CC=C3OC) =O) C=C2) =O

• Molecular Formula:

  C23H20ClNO5S

• Molecular Weight:

  457.93

• References & Citations:

  [1]Jeon KH, et al. Computer-aided discovery of novel AMPK activators through virtual screening and SAR-driven synthesis. Eur J Med Chem. 2025 Apr 5;287:117318.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2252336-04-0