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AMPK activator 16

CAT: 0804-HY-170931Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170931Size:1 Each
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Description
AMPK activator 16 (compound 6) is a AMP-activated protein kinase (AMPK) inhibitor. AMPK activator 16 shows the most efficient interactions with the key residues of AMPK and demonstrates significant activation of AMPK. AMPK activator 16 increases the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) (p-ACC) and phosphorylated raptor (p-raptor), in N2a cells[1].
CAS Number
2252336-04-0
UNSPSC
12352005
Target
Acetyl-CoA Carboxylase; AMPK
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Smiles
O=S(C1=CC=C(Cl)C=C1)(NC2=CC=C(C(/C=C/C3=CC(OC)=CC=C3OC)=O)C=C2)=O
Molecular Formula
C23H20ClNO5S
Molecular Weight
457.93
References & Citations
[1]Jeon KH, et al. Computer-aided discovery of novel AMPK activators through virtual screening and SAR-driven synthesis. Eur J Med Chem. 2025 Apr 5;287:117318.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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