AMPK activator 2

• Description:

  AMPK activator 2 (compound 7a), a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) [1].

• UNSPSC:

  12352005

• Target:

  AMPK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ampk-activator-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N=C(NC(NC1=CC=C(C(F)(F)F)C=C1)=N)NCC(C)C

• Molecular Formula:

  C13H18F3N5

• Molecular Weight:

  301.31

• References & Citations:

  [1]Di Xiao, et al. Synthesis, biological evaluation and anti-proliferative mechanism of fluorine-containing proguanil derivatives. Bioorg Med Chem. 2020 Jan 15;28 (2) :115258.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AMPK

• CAS Number:

  [2410961-69-0]