AMPK activator 15

CAT: 0804-HY-168639Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-168639Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AP39 prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. AP39 prodrug 1 induces ROS-dependent mild mitochondrial uncoupling, activating mitochondria-associated AMPK to suppress Palmitic acid (PA) (HY-N0830) -induced lipid deposition in hepatocytes[1].
UNSPSC
12352005
Target
AMPK; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ampk-activator-15.html
Smiles
O=C1OC2=CC(OCC3=CC(OCCCC[P+](C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)=CC=C3[N+]([O-])=O)=CC=C2C=C1COC(OC7=C(C(C)=CC(C)=C7)C(C)(CC(S)=O)C)=O.[Br-]
Molecular Formula
C53H51BrNO10PS
Molecular Weight
1004.92
References & Citations
[1]Zhang X, et al. A Spatiotemporally Controlled and Mitochondria-Targeted Prodrug of Hydrogen Sulfide Enables Mild Mitochondrial Uncoupling for the Prevention of Lipid Deposition. J Med Chem. 2024 Nov 14;67 (21) :19188-19199.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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