AMPK activator 15

• Description:

  AP39 prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. AP39 prodrug 1 induces ROS-dependent mild mitochondrial uncoupling, activating mitochondria-associated AMPK to suppress Palmitic acid (PA) (HY-N0830) -induced lipid deposition in hepatocytes[1].

• UNSPSC:

  12352005

• Target:

  AMPK; Mitochondrial Metabolism

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/ampk-activator-15.html

• Smiles:

  O=C1OC2=CC(OCC3=CC(OCCCC[P+](C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)=CC=C3[N+]([O-])=O)=CC=C2C=C1COC(OC7=C(C(C)=CC(C)=C7)C(C)(CC(S)=O)C)=O.[Br-]

• Molecular Formula:

  C53H51BrNO10PS

• Molecular Weight:

  1004.92

• References & Citations:

  [1]Zhang X, et al. A Spatiotemporally Controlled and Mitochondria-Targeted Prodrug of Hydrogen Sulfide Enables Mild Mitochondrial Uncoupling for the Prevention of Lipid Deposition. J Med Chem. 2024 Nov 14;67 (21) :19188-19199.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported