AMPK activator 17

• Description:

  AMPK activator 17 (Compound 10g) is an orally active AMPK activator. AMPK activator 17 has significant anti-adipogenic (IC50: 3.4 μM) and dyslipidemia-modifying activities. AMPK activator 17 inhibits the early stages of adipocyte differentiation (mitotic clonal expansion) by activating the AMPK pathway. AMPK activator 17 can enhance mitochondrial function and fatty acid oxidation in mature adipocytes. AMPK activator 17 improves dyslipidemia by promoting reverse cholesterol transport. AMPK activator 17 can be used in the study of obesity and related metabolic diseases (such as type 2 diabetes and cardiovascular disease) [1].

• UNSPSC:

  12352101

• Target:

  AMPK

• Related Pathways:

  Epigenetics; PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease; Cardiovascular Disease

• Smiles:

  O=C (C1=C (C) NC (NC1C2=CN=CS2) =O) OCC3=CC (C4=CC=C (Cl) C=C4) =NO3

• Molecular Formula:

  C19H15ClN4O4S

• Molecular Weight:

  430.86

• References & Citations:

  [1]Alisha Ansari, et al. Design, synthesis, and biological evaluation of isoxazole-dihydropyrimidinone hybrids as potential modulators of adipogenesis and dyslipidemia. European Journal of Medicinal Chemistry. Volume 294. 2025,117746, ISSN 0223-5234.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported