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PT-65

CAT: 804-HY-153166-01Size: 1 mgDry Ice: NoHazardous: No
1 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PT-65 is a potent and selective GSK3 PROTAC degrader with the highest degradation capacity of GSK3α (DC50= 28.3 nM) and GSK3β (DC50= 34.2 nM) in SH-SY5Y cells. PT-65 can be used in Alzheimer's disease research[1]. (Pink: GSK3 inhibitor (HY-15761) ; Black: linker; Blue: CRBN Ligand (HY-10984) )
CAS Number
[2721998-87-2]
UNSPSC
12352005
Target
GSK-3; PROTACs
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; PROTAC; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pt-65.html
Purity
99.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(N)N=CC(C2=CC=C(S(=O)(N3CCN(CCCCC4=CN(CCOCCOCCOCCOCCOCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)N=N4)CC3)=O)C=C2)=N1)NC8=CC=CN=C8
Molecular Formula
C51H63N13O12S
Molecular Weight
1082.19
References & Citations
[1]Qu L, et al. Discovery of PT-65 as a highly potent and selective Proteolysis-targeting chimera degrader of GSK3 for treating Alzheimer's disease. Eur J Med Chem. 2021 Dec 15;226:113889.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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