PT-ttpy

• Description :

  Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs) .

• CAS Number :

  [727721-37-1]

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  DNA/RNA Synthesis; G-quadruplex; Mitosis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pt-ttpy.html

• Purity :

  98.0

• Solubility :

  DMSO : 0.2 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  [Cl-][Pt+2]12[N]3=C(C4=CC(C5=CC=C(C)C=C5)=CC(C6=[N]2C=CC=C6)=[N]41)C=CC=C3.[Cl-]

• Molecular Formula :

  C22H17Cl2N3Pt

• Molecular Weight :

  589.38

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]P.P. Losada et al.Fresenius Journal of Analytical Chemistry1993

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported