Multi-target Pt

• UNSPSC Description:

  Multi-target Pt (IV), an antitumor agent, suppresses the IKKβ phosphorylation, IκBα phosphorylation and NF-κB p65 phosphorylation and nuclear translocation, leading to blocked the NF-kB signal pathway[1].

• Target Antigen:

  IKK; NF-κB

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/multi-target-pt.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(C(OC)=CC(C(/C=C/C2=CC=C(C(OCCOC(CCCC(O[Pt]3([NH2][C@@H]4[C@H](CCCC4)[NH2]3)(OC5=O)(OC5=O)Cl)=O)=O)=C2)OC)=O)=C1)OC

• Molecular Weight:

  934.25

• References & Citations:

  [1]Meng Wang, et al. Dual-targeting tumor cells hybrids derived from Pt(IV) species and NF-κB inhibitors enables cancer therapy through mitochondrial dysfunction and ER stress and overcomes cisplatin resistance. European Journal of Medicinal Chemistry Available online 25 December 2023, 116095

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3041997-77-4