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Multi-target Pt

CAT: 0804-HY-162092Size: 1 EachDry Ice: NoHazardous: No
CAT#: HY-162092Size: 1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Multi-target Pt (IV), an antitumor agent, suppresses the IKKβ phosphorylation, IκBα phosphorylation and NF-κB p65 phosphorylation and nuclear translocation, leading to blocked the NF-kB signal pathway[1].
CAS Number
[3041997-77-4]
UNSPSC
12352211
Target
IKK; NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/multi-target-pt.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C(OC)=CC(C(/C=C/C2=CC=C(C(OCCOC(CCCC(O[Pt]3([NH2][C@@H]4[C@H](CCCC4)[NH2]3)(OC5=O)(OC5=O)Cl)=O)=O)=C2)OC)=O)=C1)OC
Molecular Formula
C34H43ClN2O14Pt
Molecular Weight
934.25
References & Citations
[1]Meng Wang, et al. Dual-targeting tumor cells hybrids derived from Pt (IV) species and NF-κB inhibitors enables cancer therapy through mitochondrial dysfunction and ER stress and overcomes cisplatin resistance. European Journal of Medicinal Chemistry Available online 25 December 2023, 116095
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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