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PT-S58

CAT: 0804-HY-116259Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-116259Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PT-S58, a GSK0660 derivative, is a PPARβ/δ full antagonist with an IC50 value of 98 nM. PT-S58 inhibits the agonist-induced transcriptional activity of PPARβ/δ in vitro[1].
CAS Number
[1356497-92-1]
UNSPSC
12352005
Target
PPAR
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
O=C(C1=C(S(=O)(NC2=CC=C(NC(C)(C)C)C=C2OC)=O)C=CS1)OC
Molecular Formula
C17H22N2O5S2
Molecular Weight
398.50
References & Citations
[1]Naruhn S, et al. High-affinity peroxisome proliferator-activated receptor β/δ-specific ligands with pure antagonistic or inverse agonistic properties. Mol Pharmacol. 2011 Nov;80 (5) :828-38.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARβ/δ

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