PT-2385

CAT: 0804-HY-12867-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12867-01Size:2 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM[1][2].
CAS Number
[1672665-49-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PT-2385.html
Purity
99.95
Solubility
DMSO : ≥ 50 mg/mL
Smiles
N#CC1=CC(F)=CC(OC2=CC=C(S(=O)(C)=O)C3=C2CC(F)(F)[C@H]3O)=C1
Molecular Formula
C17H12F3NO4S
Molecular Weight
383.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Eli Wallace, Ph.D. PT2385: HIF-2α Antagonist for the Treatment of VHL Mutant ccRCC. 12th International VHL Medical Symposium April 8, 2016.|[2]Xie C, et al. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nat Med. 2017 Nov;23 (11) :1298-1308.|[3]Wallace EM, et al. A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma. Cancer Res. 2016 Sep 15;76 (18) :5491-500.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Related Products

CatalogName
HY-1565625-PT
HY-170872-01PT-129
HY-W543137-01PT-ttpy
HY-163087-01PT-91
HY-116259PT-S58
HY-100035-01PT-262
HY-161509PT-88
HY-153166-01PT-65
HY-160695-01PT-179
HY-162092Multi-target Pt

Alternative Products

CatalogName
MBS131232-01PT-2385
A21561-1PT-2385 1mg
A21561-5PT-2385 5mg
A21561-50PT-2385 50mg
A21561-100PT-2385 100mg
A21561-25PT-2385 25mg
A21561-2PT-2385 2mg
A21561-10PT-2385 10mg
A21561-10mM-DPT-2385 10mM * 1mL in DMSO
ARI0099PT-67

Popular Products