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AChE/Nrf2 modulator 1

CAT: 0804-HY-152037Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-152037Size:1 Each
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Description
AChE/Nrf2 modulator 1 is an orally active acetylcholinesterase (AChE) /nuclear factor erythroid 2-related factor 2 (Nrf2) modulator. AChE/Nrf2 modulator 1 has Nrf2 inductive activity and AChE inhibitory activity for eeAChE and hAChE with IC50 values of 0.07 μM and 0.38 μM, respectively. AChE/Nrf2 modulator 1 can be used for the research of Alzheimer's disease[1].
CAS Number
2417117-84-9
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Keap1-Nrf2
Type
Reference compound
Related Pathways
Neuronal Signaling; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-nrf2-modulator-1.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C=N1)C2=NOC(C3=CC(OCC4CCN(CC4)CC5=CC(F)=CC=C5)=CC=C3)=N2
Molecular Formula
C27H27FN4O2
Molecular Weight
458.53
References & Citations
[1]Yuanyuan Wang, et al. Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease. Eur J Med Chem. 2022 Dec 15;244:114806.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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