AChE/Nrf2 modulator 1

AChE/Nrf2 modulator 1

• CAS Number: 2417117-84-9
• UNSPSC Description: AChE/Nrf2 modulator 1 is an orally active acetylcholinesterase (AChE)/nuclear factor erythroid 2-related factor 2 (Nrf2) modulator. AChE/Nrf2 modulator 1 has Nrf2 inductive activity and AChE inhibitory activity for eeAChE and hAChE with IC50 values of 0.07 μM and 0.38 μM, respectively. AChE/Nrf2 modulator 1 can be used for the research of Alzheimer's disease[1].
• Target Antigen: Cholinesterase (ChE); Keap1-Nrf2
• Type: Reference compound
• Related Pathways: Neuronal Signaling;NF-κB
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/ache-nrf2-modulator-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CC=C(C=N1)C2=NOC(C3=CC(OCC4CCN(CC4)CC5=CC(F)=CC=C5)=CC=C3)=N2
• Molecular Weight: 458.53
• References & Citations: [1]Yuanyuan Wang, et al. Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease. Eur J Med Chem. 2022 Dec 15;244:114806.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported