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AChE/Aβ-IN-1

CAT: 0804-HY-155733Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155733Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE/Aβ-IN-1 (compound 32) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with an IC50 of 86 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC50 of 3.876 μM. AChE/Aβ-IN-1 also inhibits Aβ aggregation and shows good blood-brain barrier permeability and neuroprotection. AChE/Aβ-IN-1 improves cognitive and spatial memory impairment in rats model[1].
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; iGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-aβ-in-1.html
Solubility
10 mM in DMSO
Smiles
BrC1=CC=C(C=C1)CN2C=C(N=N2)CNC34CC(C5)CC(C4)CC5C3
Molecular Formula
C20H25BrN4
Molecular Weight
401.34
References & Citations
[1]Gutti G, et al. Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease. Eur J Med Chem. 2023 Nov 5;259:115670.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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