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AChE/BChE-IN-1

CAT: 0804-HY-131971Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-131971Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE/BChE-IN-1 is a potent and brain-penetrant dual inhibitor of Acetylcholinesterase and Butyrylcholinesterase, with IC50s of 1.06 and 7.3 nM for hAChE and hBChE, respectively. AChE/BChE-IN-1 also has antioxidant activity. AChE/BChE-IN-1 can be used for the research of Alzheimer’s disease[1].
CAS Number
2720624-42-8
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-bche-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=CC=C(O)C(OC)=C1)CC2=CN(CCCCC3=CC(C4)CC5=NC6=CC(Cl)=CC=C6C(N)=C5C4C3)N=N2
Molecular Formula
C32H35ClN6O3
Molecular Weight
587.11
References & Citations
[1]Viayna E, et, al. Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice. J Med Chem. 2020 Dec 28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

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