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HCAIX-IN-16

CAT: 0804-HY-151630Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151630Size:1 Each
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Description
HCAIX-IN-16 (Compound 12d) is hCA IX inhibitor, with Ki values of 190.0 and 187.9 nM for hCA IX and hCA XII, respectively. hCAIX-IN-16 can arrest the cell cycle of breast cancer MDA-MB-468 in G0-G1 and S phase and induce apoptosis. hCAIX-IN-16 shows good broad-spectrum anticancer activity and can be used for cancer research[1].
CAS Number
2849348-38-3
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaix-in-16.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(NC2=NC(N)=NC(/C(C#N)=C/C3=CC=C(N(C)C)C=C3)=N2)C=C1)(N)=O
Molecular Formula
C20H20N8O2S
Molecular Weight
436.49
References & Citations
[1]Zain-Alabdeen AI, et al. Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX. Sci Rep. 2022 Oct 6;12 (1) :16756.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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