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BChE-IN-14

CAT: 0804-HY-151389Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151389Size:1 Each
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Description
BChE-IN-14 (compound 19c) is a selective butyrylcholinesterase (BChE) inhibitor with IC50s of 0.23 and 0.011 μM for eqBChE and hBChE, respectively. BChE-IN-14 shows good blood brain barrier permeation and primary cell safety. BChE-IN-14 is able to restore cognitive impairment in vivo, it can be used for the research of Alzheimer’s disease[1].
CAS Number
2700896-78-0
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bche-in-14.html
Solubility
10 mM in DMSO
Smiles
CCCCN(CC1=CC=C2C=CC=CC2=C1)CCCC3=CC=CC=C3
Molecular Formula
C24H29N
Molecular Weight
331.49
References & Citations
[1]Lu X, et al. Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2022 Sep 2;243:114729.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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