AChE-IN-22

• Description:

  AChE-IN-22 (compound 10q) is a selective acetylcholinesterase (AChE) inhibitor against AChE and BuChE with the IC50 values of 0.88 μM and 10 μM, respectively. AChE-IN-22 can bind to both the CAS (catalytic active site) and PAS (peripheral anionic site) of AChE and has the potential for the research of Alzheimer's disease[1].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ache-in-22.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC=CS1)CC2=NC=C(C=N2)C(N(CCCOC3=CC=C(C=C3)[N+]([O-])=O)C)=O

• Molecular Formula:

  C21H20N4O5S

• Molecular Weight:

  440.47

• References & Citations:

  [1]Chuang Han, et al. Design, synthesis and evaluation of 2- (2-oxoethyl) pyrimidine-5-carboxamide derivatives as acetylcholinesterase inhibitors. Bioorg Med Chem Lett. 2022 Sep 15;72:128873.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE

• CAS Number:

  [3032264-62-0]