CDK2-IN-11

• Description :

  CDK2-IN-11 (compound 9d) is a potent CDK2 inhibitor with an IC50 of 6.4 μM, and KI values of 23.4 nM, 56.3 nM and 44.3 nM for hCA II, hCA IX and hCA XII, respectively. CDK2-IN-11 can be used for researching anticancer[1].

• UNSPSC :

  12352005

• Target :

  Carbonic Anhydrase; CDK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cdk2-in-11.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(C1=CC=C(/N=N/C2=C3N=CC=C(C4=CC=C(Cl)C=C4)N3N=C2N)C=C1)(N)=O

• Molecular Formula :

  C18H14ClN7O2S

• Molecular Weight :

  427.87

• References & Citations :

  [1]Said MA, et al. Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. Eur J Med Chem. 2020 Mar 1;189:112019.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CA II; CA IX; CA XII

• CAS Number :

  [2410402-82-1]