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CDK2-IN-11

CAT: 0804-HY-150572Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150572Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK2-IN-11 (compound 9d) is a potent CDK2 inhibitor with an IC50 of 6.4 μM, and KI values of 23.4 nM, 56.3 nM and 44.3 nM for hCA II, hCA IX and hCA XII, respectively. CDK2-IN-11 can be used for researching anticancer[1].
CAS Number
2410402-82-1
UNSPSC
12352005
Target
Carbonic Anhydrase; CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk2-in-11.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(/N=N/C2=C3N=CC=C(C4=CC=C(Cl)C=C4)N3N=C2N)C=C1)(N)=O
Molecular Formula
C18H14ClN7O2S
Molecular Weight
427.87
References & Citations
[1]Said MA, et al. Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. Eur J Med Chem. 2020 Mar 1;189:112019.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA IX; CA XII

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