CDK2-IN-50

• Description :

  CDK2-IN-50 is a CDK2 inhibitor (IC50 = 0.77 nM) . CDK2-IN-50 can induce G1 phase arrest, indicating that it has an effective CDK2/cyclin E targeting mechanism. CDK2-IN-50 also has a significant pro-apoptotic effect. CDK2-IN-50 can be used for the study of breast cancer[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; CDK

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Field of Research :

  Cancer

• Smiles :

  O=C(NC1=CC=C(C)C=C1)C2=C(N)C3=C(S2)N=C4CCCCCC4=C3C5=CC=C(OC)C=C5

• Molecular Formula :

  C27H27N3O2S

• Molecular Weight :

  457.59

• References & Citations :

  [1]Ibrahim OF, et al. CDK2 inhibitors: rationally directed discovery of a novel potent lead derived from cyclohepta[e]thieno[2,3-b]pyridine. RSC Med Chem. 2025 Jul 24.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDK2