TRK-IN-22

• Description:

  TRK-IN-22 (compound 11) is a TRK inhibitor. TRK-IN-22 (compound 11), a typical type I inhibitor, covers the ATP-binding pocket of TRKA[1].

• UNSPSC:

  12352005

• Target:

  Trk Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/trk-in-22.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CC(CNC2=C(C=NC(NC3=CC=CC=C3)=N2)Cl)=CC=C1

• Molecular Formula:

  C17H14ClFN4

• Molecular Weight:

  328.77

• References & Citations:

  [1]Tianxiao Wu , et al. Rational drug design to explore the structure-activity relationship (SAR) of TRK inhibitors with 2,4-diaminopyrimidine scaffold. Eur J Med Chem. 2022 Feb 15;230:114096.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported