LSD1-IN-26

CAT: 0804-HY-149978Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-149978Size:1 Each
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Description
LSD1-IN-26 (compound 12u) is a potent LSD1 inhibitor, with an IC50 of 25.3 nM. LSD1-IN-26 also inhibits MAO-A (IC50=1234.57 nM) and MAO-B (IC50=3819.27 nM) . LSD1-IN-26 significantly induces apoptosis in MGC-803 cells. LSD1-IN-26 can be used for gastric cancer research[1].
CAS Number
[3041141-72-1]
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; Histone Demethylase; IAP; Monoamine Oxidase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lsd1-in-26.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCN(CC1)C2=CC(Cl)=C(C=C2)Cl)C3=CC=CC(CN[C@@H]4C[C@H]4C5=CC=C(C(F)=C5)F)=C3
Molecular Formula
C27H25Cl2F2N3O
Molecular Weight
516.41
References & Citations
[1]Ma QS, et al. Discovery of novel tranylcypromine-based derivatives as LSD1 inhibitors for gastric cancer treatment. Eur J Med Chem. 2023 May 5;251:115228.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Caspase 3; Caspase 9; cIAP-1; KDM1/LSD1; MAO-A; MAO-B

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