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LSD1-IN-25

CAT: 0804-HY-149968Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149968Size:1 Each
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Description
LSD1-IN-25 (Compound 9j) is a potent, selective and orally active LSD1 inhibitor with an IC50 of 46 nM (Ki = 30.3 nM) . LSD1-IN-25 induces cancer cell apoptosis[1].
CAS Number
2911585-60-7
UNSPSC
12352005
Target
Apoptosis; Histone Demethylase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lsd1-in-25.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=CC(CN2C(N=C(SCCC)N=C3OC4=C(OC)C=C(CN[C@H]5C[C@@H]5C6=CC=CC=C6)C=C4OC)=C3N=N2)=C1
Molecular Formula
C32H33ClN6O3S
Molecular Weight
617.16
References & Citations
[1]Li Z, et al. Design, synthesis and in vitro/in vivo anticancer activity of tranylcypromine-based triazolopyrimidine analogs as novel LSD1 inhibitors. Eur J Med Chem. 2023 May 5;253:115321.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1

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