HIF-2α-IN-9

HIF-2α-IN-9

• CAS Number: 2648334-36-3
• UNSPSC Description: HIF-2α-IN-9 (compound 35r) is an inhibitor ofHIF-2α. HIF-2α-IN-9 inhibits VEGF-A (IC50=305 nM), and regulates growth-promoting genes in tumor cells, reactivates macrophage-mediated tumor immunity[1].
• Target Antigen: HIF/HIF Prolyl-Hydroxylase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hif-2α-in-9.html
• Solubility: 10 mM in DMSO
• Smiles: FC1(F)[C@@H](O)C2=C(S(=O)(C)=O)SC(OC[C@H](C)C(F)(F)F)=C2C1
• Molecular Weight: 380.35
• References & Citations: [1]Buchstaller H P, et al. Discovery of Cycloalkyl [c] thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2伪 Inhibitors[J]. Journal of Medicinal Chemistry, 2023..
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported