HIF-2α-IN-3

HIF-2α-IN-3

• CAS Number: 313964-19-1
• UNSPSC Description: HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 μM and a KD of 1.1 μM. Anticancer agent[1].
• Target Antigen: HIF/HIF Prolyl-Hydroxylase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hif-2α-in-3.html
• Purity: 99.89
• Solubility: DMSO : 12.5 mg/mL (ultrasonic)
• Smiles: O=[N+](C1=C(NC2=CC=C(Cl)C([N+]([O-])=O)=C2)C=CC3=NON=C31)[O-]
• Molecular Weight: 335.66
• References & Citations: [1]Rogers JL, et al. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J Med Chem. 2013 Feb 28;56(4):1739-47.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported