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HIF-2α-IN-14

CAT: 0804-HY-163601Size: 1 EachDry Ice: NoHazardous: No
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Description
HIF-2α-IN-14 (18) is a HIF-2α inhibitor, with an IC50 of 0.27 μM[1].
CAS Number
3033981-37-9
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hif-2α-in-14.html
Smiles
O=C(N1CC(F)(C(C12CCCC2)O)F)C3=NC(Cl)=C(C=C3)OC(F)F
Molecular Formula
C15H15ClF4N2O3
Molecular Weight
382.74
References & Citations
[1]Zhiguo Liu, et al. Pyridinylamide derivative, pharmaceutical composition comprising same, and medical use thereof. Patent. WO2024067709A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Hif-2|A-IN-14
CAS Number3033981-37-9
PubChem CID171714332
IUPAC Name[6-chloro-5-(difluoromethoxy)-2-pyridinyl]-(3,3-difluoro-4-hydroxy-1-azaspiro[4.4]nonan-1-yl)methanone
Molecular FormulaC15H15ClF4N2O3
Molecular Weight382.74
XLogP3.4
Topological Polar Surface Area62.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity519
SMILES
C1CCC2(C1)C(C(CN2C(=O)C3=NC(=C(C=C3)OC(F)F)Cl)(F)F)O
InChI
InChI=1S/C15H15ClF4N2O3/c16-10-9(25-13(17)18)4-3-8(21-10)11(23)22-7-15(19,20)12(24)14(22)5-1-2-6-14/h3-4,12-13,24H,1-2,5-7H2
InChIKey
FRESBKQOSRAPAG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hif-2|A-IN-14
CAS: 3033981-37-9
CID: 171714332
Formula: C15H15ClF4N2O3
MW: 382.74
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight382.74
XLogP33.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass382.0707327
Monoisotopic Mass382.0707327
Topological Polar Surface Area62.7 Ų
Heavy Atom Count25
Formal Charge0
Complexity519
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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