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HIF-2α-IN-4

CAT: 0804-HY-136748-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136748-01Size:5 mg
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Description
HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing[1].
CAS Number
882268-69-1
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hif-2α-in-4.html
Purity
99.96
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(N/N=C(C#N)/S(=O)(C)=O)C=CS1)OC
Molecular Formula
C9H9N3O4S2
Molecular Weight
287.32
Precautions
H315, H319, H335
References & Citations
[1]Zimmer M, et al. Small-molecule inhibitors of HIF-2α translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32 (6) :838-848.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

methyl 3-[(2E)-2-[cyano(methylsulfonyl)methylidene]hydrazinyl]thiophene-2-carboxylate
CAS Number882268-69-1
PubChem CID6375097
IUPAC Namemethyl 3-[(2E)-2-[cyano(methylsulfonyl)methylidene]hydrazinyl]thiophene-2-carboxylate
Molecular FormulaC9H9N3O4S2
Molecular Weight287.3
XLogP2.1
Topological Polar Surface Area145
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count18
Formal Charge0
Complexity500
SMILES
COC(=O)C1=C(C=CS1)N/N=C(\C#N)/S(=O)(=O)C
InChI
InChI=1S/C9H9N3O4S2/c1-16-9(13)8-6(3-4-17-8)11-12-7(5-10)18(2,14)15/h3-4,11H,1-2H3/b12-7+
InChIKey
OOGAPDPPVHJYGJ-KPKJPENVSA-N
Chemical Structure
2D Structure
2D structure of methyl 3-[(2E)-2-[cyano(methylsulfonyl)methylidene]hydrazinyl]thiophene-2-carboxylate
CAS: 882268-69-1
CID: 6375097
Formula: C9H9N3O4S2
MW: 287.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight287.3
XLogP32.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass287.00344812
Monoisotopic Mass287.00344812
Topological Polar Surface Area145 Ų
Heavy Atom Count18
Formal Charge0
Complexity500
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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