HIF-2α-IN-4

• UNSPSC Description:

  HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing[1].

• Target Antigen:

  HIF/HIF Prolyl-Hydroxylase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hif-2α-in-4.html

• Smiles:

  O=C(C1=C(N/N=C(C#N)/S(=O)(C)=O)C=CS1)OC

• Molecular Weight:

  287.32

• References & Citations:

  [1]Zimmer M, et al. Small-molecule inhibitors of HIF-2α translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32(6):838-848.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  882268-69-1