MTHFD2-IN-3

• Description :

  MTHFD2-IN-3 (compound 10) is a potent methylenetetrahydrofolate dehydrogenase (MTHFD2) inhibitor[1].

• UNSPSC :

  12352005

• Target :

  Methylenetetrahydrofolate Dehydrogenase (MTHFD)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mthfd2-in-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CS(=O)(CC1=CC=CC2=C1OC(C3=C2CCN(C3)C(C4=CC=C(C=C4)C(O)=O)=O)=O)=O

• Molecular Formula :

  C22H19NO7S

• Molecular Weight :

  441.45

• References & Citations :

  [1]Jha V, et al. Binding Analysis and Structure-Based Design of Tricyclic Coumarin-Derived MTHFD2 Inhibitors as Anticancer Agents: Insights from Computational Modeling. ACS Omega. 2023 Apr 12;8 (16) :14440-14458.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported