MTHFD2-IN-3

• UNSPSC Description:

  MTHFD2-IN-3 (compound 10) is a potent methylenetetrahydrofolate dehydrogenase (MTHFD2) inhibitor[1].

• Target Antigen:

  Methylenetetrahydrofolate Dehydrogenase (MTHFD)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mthfd2-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CS(=O)(CC1=CC=CC2=C1OC(C3=C2CCN(C3)C(C4=CC=C(C=C4)C(O)=O)=O)=O)=O

• Molecular Weight:

  441.45

• References & Citations:

  [1]Jha V, et al. Binding Analysis and Structure-Based Design of Tricyclic Coumarin-Derived MTHFD2 Inhibitors as Anticancer Agents: Insights from Computational Modeling. ACS Omega. 2023 Apr 12;8(16):14440-14458.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported