MTHFD2-IN-1

• Description :

  MTHFD2-IN-1 (compound 12) is a potent methylenetetrahydrofolate dehydrogenase (MTHFD2) inhibitor[1].

• UNSPSC :

  12352005

• Target :

  Methylenetetrahydrofolate Dehydrogenase (MTHFD)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mthfd2-in-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CC=C(C=C1)C(N2CCC3=C(C(OC4=C3C=CC=C4C5CC(C5)O)=O)C2)=O)O

• Molecular Formula :

  C24H21NO6

• Molecular Weight :

  419.43

• References & Citations :

  [1]Jha V, et al. Binding Analysis and Structure-Based Design of Tricyclic Coumarin-Derived MTHFD2 Inhibitors as Anticancer Agents: Insights from Computational Modeling. ACS Omega. 2023 Apr 12;8 (16) :14440-14458.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported