MTHFD2-IN-6

• Description:

  MTHFD2-IN-6 (compound 41) is a potent and selective MTHFD2 inhibitor. MTHFD2-IN-6 inhibits MTHFD1 and MTHFD2 with IC50s of 19.05 and 1.46 μM, respectively[1].

• UNSPSC:

  12352005

• Target:

  Methylenetetrahydrofolate Dehydrogenase (MTHFD)

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Smiles:

  O=C(C1=C(O)C=C(O)C(C/C=C(C)\C)=C1O)/C=C/C2=CC=C(Cl)C(OC)=C2

• Molecular Formula:

  C21H21ClO5

• Molecular Weight:

  388.84

• References & Citations:

  [1]Hu Y, et al. Hit to lead optimization of isopentenyl chalcones as novel MTHFD2 inhibitors for cancer treatment: design, synthesis, in-vitro, in-vivo and in-silico studies. Eur J Med Chem. 2025 Aug 5;292:117703.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3077252-76-4]