MTHFD2-IN-6

CAT: 0804-HY-172910Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172910Size:1 Each
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Description
MTHFD2-IN-6 (compound 41) is a potent and selective MTHFD2 inhibitor. MTHFD2-IN-6 inhibits MTHFD1 and MTHFD2 with IC50s of 19.05 and 1.46 μM, respectively[1].
CAS Number
[3077252-76-4]
UNSPSC
12352005
Target
Methylenetetrahydrofolate Dehydrogenase (MTHFD)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(C1=C(O)C=C(O)C(C/C=C(C)\C)=C1O)/C=C/C2=CC=C(Cl)C(OC)=C2
Molecular Formula
C21H21ClO5
Molecular Weight
388.84
References & Citations
[1]Hu Y, et al. Hit to lead optimization of isopentenyl chalcones as novel MTHFD2 inhibitors for cancer treatment: design, synthesis, in-vitro, in-vivo and in-silico studies. Eur J Med Chem. 2025 Aug 5;292:117703.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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