MTHFD2-IN-6

• Description :

  MTHFD2-IN-6 (compound 41) is a potent and selective MTHFD2 inhibitor. MTHFD2-IN-6 inhibits MTHFD1 and MTHFD2 with IC50s of 19.05 and 1.46 μM, respectively[1].

• UNSPSC :

  12352005

• Target :

  Methylenetetrahydrofolate Dehydrogenase (MTHFD)

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Smiles :

  O=C(C1=C(O)C=C(O)C(C/C=C(C)\C)=C1O)/C=C/C2=CC=C(Cl)C(OC)=C2

• Molecular Formula :

  C21H21ClO5

• Molecular Weight :

  388.84

• References & Citations :

  [1]Hu Y, et al. Hit to lead optimization of isopentenyl chalcones as novel MTHFD2 inhibitors for cancer treatment: design, synthesis, in-vitro, in-vivo and in-silico studies. Eur J Med Chem. 2025 Aug 5;292:117703.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3077252-76-4]