MTHFD2-IN-4

• Description :

  MTHFD2-IN-4, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. MTHFD2-IN-4 can be used in research of cancer[1].

• UNSPSC :

  12352005

• Target :

  Methylenetetrahydrofolate Dehydrogenase (MTHFD)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mthfd2-in-4.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1OC2=C(C3=C1CN(CC3)C(C4=CC=C(C=C4)C([O-])(C(F)(F)F)C(F)(F)F)=O)C=CC(C5CNCCO5)=C2

• Molecular Formula :

  C26H21F6N2O5-

• Molecular Weight :

  555.45

• References & Citations :

  [1]Jha V, et, al. Binding Analysis and Structure-Based Design of Tricyclic Coumarin-Derived MTHFD2 Inhibitors as Anticancer Agents: Insights from Computational Modeling. ACS Omega. 2023 Apr 12;8 (16) :14440-14458.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported