MTHFD2-IN-4 (sodium)

• UNSPSC Description:

  MTHFD2-IN-4 sodium, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. MTHFD2-IN-4 sodium can be used in research of cancer[1].

• Target Antigen:

  Methylenetetrahydrofolate Dehydrogenase (MTHFD)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mthfd2-in-4-sodium.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1OC2=C(C3=C1CN(CC3)C(C4=CC=C(C=C4)C(C(F)(F)F)(O[Na])C(F)(F)F)=O)C=CC(C5CNCCO5)=C2

• Molecular Weight:

  578.44

• References & Citations:

  [1]Jha V, et, al. Binding Analysis and Structure-Based Design of Tricyclic Coumarin-Derived MTHFD2 Inhibitors as Anticancer Agents: Insights from Computational Modeling. ACS Omega. 2023 Apr 12;8(16):14440-14458.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported