MTHFD2-IN-5

• Target:

  Dehydrogenase

• Related Pathways:

  Metabolism

• Bioactivity:

  MTHFD2-IN-5 (Compound 16e) is a selective inhibitor of MTHFD2 with an IC50 of 66 nM. It inhibits the proliferation of MOLM-14 cells with a GI50 of 720 nM and demonstrates antitumor activity in mouse models.

• Smiles:

  C1=CC(=C(C=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)Cl)NC(=O)NC2=C(N=C(NC2=O)N)N

• Molecular Formula:

  C17H18ClN7O7

• Molecular Weight:

  467.821

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C