TNF-α-IN-11

• UNSPSC Description:

  TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor with a KD value of 12.06 μM. TNF-α-IN-11 binds to TNF-α and blocks the activation of TNF-α-trigged caspase and NF-κB signaling pathway. TNF-α-IN-11 inhibits the phosphorylation of IκBα, as well as the nuclear translocation of NF κB p65. TNF-α-IN-11 can be used for research of TNF-α-mediated autoimmune diseases[1].

• Target Antigen:

  Caspase; NF-κB; TNF Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/tnf-α-in-11.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N(CCC1=CC=C2C(OCO2)=C1)C(C3)=O)[C@H]3NC(C4=CC=C(C(C)(C)C)C=C4)=O

• Molecular Weight:

  422.47

• References & Citations:

  [1]Yang Y, et al. Structure-Based Drug Design and Synthesis of Pyrrolidine-2,5-diones as Novel TNF-α Inhibitors. J Chem Inf Model. 2023 Jun 26;63(12):3911-3924.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2945197-77-1