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TNF-α-IN-10

CAT: 0804-HY-153330Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-153330Size:1 Each
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Description
TNF-α-IN-10 (compound 8a) is a IL-6 and TNF-α inhibitor. TNF-α-IN-10 shows anti-inflammatory activity[1].
CAS Number
2247720-56-3
UNSPSC
12352005
Target
Interleukin Related; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tnf-α-in-10.html
Solubility
10 mM in DMSO
Smiles
O=C1/C(CC2=C1C(O)=CC=C2)=C/C3=CC=C(O)C(OC)=C3
Molecular Formula
C17H14O4
Molecular Weight
282.29
References & Citations
[1]Zhi-Guo Liu, et al. A kind of 2- Asia- (3- methoxyl group -4- hydroxyls) -benzyl -1- indones analogs and application. CN108516929A.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6

Chemical Information

Tnf-|A-IN-10
CAS Number2247720-56-3
PubChem CID141532332
IUPAC Name(2E)-7-hydroxy-2-[(4-hydroxy-3-methoxyphenyl)methylidene]-3H-inden-1-one
Molecular FormulaC17H14O4
Molecular Weight282.29
XLogP3.6
Topological Polar Surface Area66.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity431
SMILES
COC1=C(C=CC(=C1)/C=C/2\CC3=C(C2=O)C(=CC=C3)O)O
InChI
InChI=1S/C17H14O4/c1-21-15-8-10(5-6-13(15)18)7-12-9-11-3-2-4-14(19)16(11)17(12)20/h2-8,18-19H,9H2,1H3/b12-7+
InChIKey
WRJDQGQOOTVPAR-KPKJPENVSA-N
Chemical Structure
2D Structure
2D structure of Tnf-|A-IN-10
CAS: 2247720-56-3
CID: 141532332
Formula: C17H14O4
MW: 282.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight282.29
XLogP33.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass282.08920892
Monoisotopic Mass282.08920892
Topological Polar Surface Area66.8 Ų
Heavy Atom Count21
Formal Charge0
Complexity431
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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