TNF-?-IN-11

• Target :

  TNF|||Others|||Caspase|||NF-?B

• Related Pathways :

  Apoptosis|||Proteases/Proteasome|||NF-?B|||Others

• Bioactivity :

  TNF-?-IN-11 (Compound 10) is a TNF-? inhibitor with a dissociation constant (K D) of 12.06 ?M. It impedes TNF-?-induced caspase activation and the NF-?B signaling pathway by binding to TNF-?, suppressing the phosphorylation of I?B? and the nuclear migration of NF-?B p65. This compound is utilized in the study of TNF-?-mediated autoimmune diseases [1].

• Molecular Formula :

  C24H26N2O5

• Molecular Weight :

  422.47

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C