TNF-α-IN-8

• UNSPSC Description:

  TNF-α-IN-8 (compound I-42) is a TNF-α inhibitor. TNF-α-IN-8 is an isoindole-imide compound. TNF-α-IN-8 can be used for the research of cancer, heart disease, osteoporosis, inflammatory, allergic and autoimmune diseases[1]. TNF-α-IN-8 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

• Target Antigen:

  TNF Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/tnf-α-in-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [N-]=[N+]=NCC(NC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)=O

• Molecular Weight:

  356.29

• References & Citations:

  [1]Robarge MJ, et al. ISOINDOLE-IMIDE COMPOUNDS, COMPOSITIONS, AND USES THEREOF. WO/2002/059106. 2002.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  444287-85-8