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TNF-α-IN-25

CAT: 0804-HY-175250Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175250Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TNF-α-IN-25 is an orally active TNF-α inhibitor. TNF-α-IN-25 shows Fluorescence Polarization (FP) assay IC50 of 103 nM in FP binding assays and L929 assay IC50 of 505 nM in cell-based assays. TNF-α-IN-25 inhibits paw swelling in the glucose-6-phosphate isomerase (GPI) arthritis model. TNF-α-IN-25 can be used for the study of arthritis[1].
UNSPSC
12352005
Target
TNF Receptor
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CC(O)(C1=NC=C(C=N1)C2=CC=C3N=C4CN5CC6=C([C@H](N4C3=N2)C5)C(F)=CC=C6)C
Molecular Formula
C23H21FN6O
Molecular Weight
416.45
References & Citations
[1]Bian Z, et al. Discovery of Orally Efficacious Bridged Piperazines as smTNF Modulators. J Med Chem. 2025 Jul 24;68 (14) :14357-14383.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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