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TNF-α-IN-6

CAT: 0804-HY-142618-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-142618-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TNF-α-IN-6 (compound 12) is an orally effective allosteric inhibitor of TNFα (KD = 6.8 nM) . TNF-α-IN-6 has anti-inflammatory effects[1].
CAS Number
2699704-20-4
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tnf-α-in-6.html
Concentration
10mM
Purity
99.58
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=NC=CC=C1CN(C2=NC(C3=CN=C(N4C[C@]5([H])N(C(NC5)=O)CC4)N=C3)=CC=C26)C(C)(C)C6=O
Molecular Formula
C26H25N9O2
Molecular Weight
495.54
References & Citations
[1]Dietrich JD, et al. Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design. J Med Chem. 2021 Jan 14;64 (1) :417-429.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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