AMPK activator 10

CAT: 0804-HY-148684Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-148684Size:1 Each
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Description
AMPK activator 10 is an orally active, potent AMPK activator with EC150 of 44.3 nM by cell-ELISA. AMPK activator 10 increases the phosphorylation levels of ACC. AMPK activator 10 exhibits a glucose lowering effect[1].
CAS Number
[1914176-03-6]
UNSPSC
12352005
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ampk-activator-10.html
Solubility
10 mM in DMSO
Smiles
COCCOC1=CC(F)=C(C(CC2)=C1)[C@H]2NC3=C(Cl)C=C(NC(O[C@H]4[C@]5([H])[C@]([C@@H](CO5)O)([H])OC4)=N6)C6=N3
Molecular Formula
C24H26ClFN4O6
Molecular Weight
520.94
References & Citations
[1]Yuusuke Tamura, et al. Identification of novel benzimidazole derivatives as highly potent AMPK activators with anti-diabetic profiles. Bioorg Med Chem Lett. 2023 Jan 1;79:129059.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPK

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