STING agonist-3

STING agonist-3

• CAS Number: 2138299-29-1
• UNSPSC Description: STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer[1].
• Target Antigen: STING
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/sting-agonist-3.html
• Purity: 99.90
• Solubility: DMSO : 41.67 mg/mL (ultrasonic)
• Smiles: O=C(N)C1=CC=C(N(C(NC(C2=CC(C)=NN2CC)=O)=N3)C/C=C/CN4C5=C(N=C4NC(C6=CC(C)=NN6CC)=O)C=C(C(N)=O)C=C5OCCCO)C3=C1
• Molecular Weight: 750.81
• References & Citations: [1]Adam Kenneth, et al. Heterocyclic amides useful as protein modulators.patent WO2017175147A1|[2]Ramanjulu JM, Pesiridis GS, Yang J, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity [published correction appears in Nature. 2019 Jun;570(7761):E53. doi: 10.1038/s41586-019-1265-5]. Nature. 2018;564(7736):439-443.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported