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AChE/HDAC-IN-1

CAT: 0804-HY-147962Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147962Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research[1].
CAS Number
2414053-06-6
UNSPSC
12352005
Target
Cholinesterase (ChE) ; HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-hdac-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCCNC1=C(CCCC2)C2=NC3=CC(Cl)=CC=C31)C4=CC=C(/C=C/C(NO)=O)C=C4
Molecular Formula
C26H27ClN4O3
Molecular Weight
478.97
References & Citations
[1]Xu A, et al. Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation. Bioorg Chem. 2020 May;98:103721.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; HDAC

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