COX-2/PI3K-IN-2

• CAS Number:

  2459938-28-2

• UNSPSC Description:

  COX-2/PI3K-IN-2 (compound 5f) is a potent PI3K inhibitor with IC50 value of 2.78 nM. COX-2/PI3K-IN-2 is a selective COX-2 inhibitor with Ki value of 3.02 nM. COX-2/PI3K-IN-2 shows anti-inflammatory and anti-cancer properties[1].

• Target Antigen:

  COX; PI3K

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;PI3K/Akt/mTOR

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cox-2-pi3k-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(/N=C1C(N(CCC)C2=C\1C=CC=C2)=O)NCN3C=CN=C3

• Molecular Weight:

  311.34

• References & Citations:

  [1]Rajesh Kumar M, et al. p-TSA.H2O mediated one-pot, multi-component synthesis of isatin derived imidazoles as dual-purpose drugs against inflammation and cancer. Bioorg Chem. 2020 Sep;102:104046.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported