COX-2/PI3K-IN-2

COX-2/PI3K-IN-2

• CAS Number: 2459938-28-2
• UNSPSC Description: COX-2/PI3K-IN-2 (compound 5f) is a potent PI3K inhibitor with IC50 value of 2.78 nM. COX-2/PI3K-IN-2 is a selective COX-2 inhibitor with Ki value of 3.02 nM. COX-2/PI3K-IN-2 shows anti-inflammatory and anti-cancer properties[1].
• Target Antigen: COX; PI3K
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;PI3K/Akt/mTOR
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cox-2-pi3k-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(/N=C1C(N(CCC)C2=C\1C=CC=C2)=O)NCN3C=CN=C3
• Molecular Weight: 311.34
• References & Citations: [1]Rajesh Kumar M, et al. p-TSA.H2O mediated one-pot, multi-component synthesis of isatin derived imidazoles as dual-purpose drugs against inflammation and cancer. Bioorg Chem. 2020 Sep;102:104046.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported