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PI3K/HDAC-IN-2

CAT: 0804-HY-146159Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146159Size:1 Each
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Description
PI3K/HDAC-IN-2 is a potent dual PI3K/HDAC inhibitor with IC50s of 226 nM, 279 nM, 467 nM, 29 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively, and IC50s of 1.3 nM, 3.4 nM, 972 nM, 17 nM, 12 nM for HDAC1, HDAC2, HDC4, HDAC6, HDAC8, respectively. PI3K/HDAC-IN-2 exhibits PI3Kδ and class I and IIb HDAC selectivity. PI3K/HDAC-IN-2 has remarkable anticancer effects[1].
CAS Number
2361418-65-5
UNSPSC
12352005
Target
HDAC; PI3K
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3k-hdac-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN=C(N(CCOC2=CC(C3=CC=C(OC)N=C3)=CC4=C(C)N=CN=C24)C)N=C1)NO
Molecular Formula
C23H23N7O4
Molecular Weight
461.47
References & Citations
[1]Kehui Zhang, et al. Bioevaluation of a dual PI3K/HDAC inhibitor for the treatment of diffuse large B-cell lymphoma. Bioorg Med Chem Lett. 2022 Sep 1;71:128825.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC4; HDAC6; HDAC8; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

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