PI3K/HDAC-IN-2

PI3K/HDAC-IN-2

• CAS Number: 2361418-65-5
• UNSPSC Description: PI3K/HDAC-IN-2 is a potent dual PI3K/HDAC inhibitor with IC50s of 226 nM, 279 nM, 467 nM, 29 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively, and IC50s of 1.3 nM, 3.4 nM, 972 nM, 17 nM, 12 nM for HDAC1, HDAC2, HDC4, HDAC6, HDAC8, respectively. PI3K/HDAC-IN-2 exhibits PI3Kδ and class I and IIb HDAC selectivity. PI3K/HDAC-IN-2 has remarkable anticancer effects[1].
• Target Antigen: HDAC; PI3K
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pi3k-hdac-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CN=C(N(CCOC2=CC(C3=CC=C(OC)N=C3)=CC4=C(C)N=CN=C24)C)N=C1)NO
• Molecular Weight: 461.47
• References & Citations: [1]Kehui Zhang, et al. Bioevaluation of a dual PI3K/HDAC inhibitor for the treatment of diffuse large B-cell lymphoma. Bioorg Med Chem Lett. 2022 Sep 1;71:128825.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported