PI3Kδ/γ-IN-2

• Description :

  PI3Kδ/γ-IN-2 is a potent PI3Kδ and PI3Kγ dual inhibitor with IC50s of 1 nM and 4.3 nM, respectively. PI3Kδ/γ-IN-2 has favorable oral bioavailability. PI3Kδ/γ-IN-2 has potential for battling B-cell malignancies[1].

• UNSPSC :

  12352005

• Target :

  PI3K

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pi3kδ-γ-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  N#CC1=C(N=C(N=C1N2CC3(C[C@H]2C4=NC5=CC=CC(Cl)=C5C(N4C6=CC=CC=C6)=O)CC3)N)N

• Molecular Formula :

  C25H21ClN8O

• Molecular Weight :

  484.94

• References & Citations :

  [1]Tao Q, et al. Structurally novel PI3Kδ/γ dual inhibitors characterized by a seven-membered spirocyclic spacer: The SARs investigation and PK evaluation. Eur J Med Chem. 2020;191:112143.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PI3Kγ; PI3Kδ

• CAS Number :

  [2412195-89-0]