PI3Kδ/γ-IN-2

• Description:

  PI3Kδ/γ-IN-2 is a potent PI3Kδ and PI3Kγ dual inhibitor with IC50s of 1 nM and 4.3 nM, respectively. PI3Kδ/γ-IN-2 has favorable oral bioavailability. PI3Kδ/γ-IN-2 has potential for battling B-cell malignancies[1].

• UNSPSC:

  12352005

• Target:

  PI3K

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pi3kδ-γ-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CC1=C (N=C (N=C1N2CC3 (C[C@H]2C4=NC5=CC=CC (Cl) =C5C (N4C6=CC=CC=C6) =O) CC3) N) N

• Molecular Formula:

  C25H21ClN8O

• Molecular Weight:

  484.94

• References & Citations:

  [1]Tao Q, et al. Structurally novel PI3Kδ/γ dual inhibitors characterized by a seven-membered spirocyclic spacer: The SARs investigation and PK evaluation. Eur J Med Chem. 2020;191:112143.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PI3Kγ; PI3Kδ

• CAS Number:

  2412195-89-0