PI3Kδ/γ-IN-2

PI3Kδ/γ-IN-2

• CAS Number: 2412195-89-0
• UNSPSC Description: PI3Kδ/γ-IN-2 is a potent PI3Kδ and PI3Kγ dual inhibitor with IC50s of 1 nM and 4.3 nM, respectively. PI3Kδ/γ-IN-2 has favorable oral bioavailability. PI3Kδ/γ-IN-2 has potential for battling B-cell malignancies[1].
• Target Antigen: PI3K
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pi3kδ-γ-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: N#CC1=C(N=C(N=C1N2CC3(C[C@H]2C4=NC5=CC=CC(Cl)=C5C(N4C6=CC=CC=C6)=O)CC3)N)N
• Molecular Weight: 484.94
• References & Citations: [1]Tao Q, et al. Structurally novel PI3Kδ/γ dual inhibitors characterized by a seven-membered spirocyclic spacer: The SARs investigation and PK evaluation. Eur J Med Chem. 2020;191:112143.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported