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PI3Kγ inhibitor 2

CAT: 0804-HY-112286Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-112286Size:1 Each
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Description
PI3Kγ inhibitor 2 (Compound 16) is an orally bioavailable, CNS-penetrant, isoform selective PI3Kγ inhibitor with a Ki of 4 nM[1].
CAS Number
1315538-79-4
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PI3K_gamma__inhibitor_2.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=CN(CC(F)(F)F)N=C2)[C@H](C)C3=NC(C4=CC(OC)=C(OC)N=C4)=CC=C31
Molecular Formula
C20H18F3N5O3
Molecular Weight
433.38
References & Citations
[1]Come JH, et al. Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS) . J Med Chem. 2018 Jun 28;61 (12) :5245-5256.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kγ

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