LSD1-IN-21

CAT: 0804-HY-147697Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-147697Size:1 Each
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Description
LSD1-IN-21 (compound 5a) is a potent and BBB-penetrated LSD1 (Lysine specific demethylase-1) inhibitor, with an IC50 of 0.956 μM. LSD1-IN-21 significantly reduces the pro-inflammatory cytokine TNF-α. LSD1-IN-21 shows good anticancer and anti-inflammatory activity[1].
UNSPSC
12352005
Target
Histone Demethylase; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lsd1-in-21.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)/C=N/NC2=C(C(C3=CC=C(C=C3)OC)=NC(SCC(C)C)=N2)C#N
Molecular Formula
C24H25N5O2S
Molecular Weight
447.55
References & Citations
[1]Tasneem S, et al. Synthesis, biological evaluation and docking studies of methylene bearing cyanopyrimidine derivatives possessing a hydrazone moiety as potent Lysine specific demethylase-1 (LSD1) inhibitors: A promising anticancer agents. Bioorg Chem. 2022 May 21;126:105885.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1

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