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HCAIX-IN-6

CAT: 0804-HY-147663Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147663Size:1 Each
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Description
Compounds 6b and 14g showed significant inhibitory effect on tumor related subtype HCA IX with low nanomolar potency, while 6k was effective on HCA XII. Compounds 6b, 14g and 6k can be considered as the leading molecules for the development of future cancer therapeutic drugs based on new mechanisms of action.
CAS Number
2451479-86-8
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaix-in-6.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC=C(C=C1)/C=C/C(NC2=CC3=C(OS(=O)(C=C3)=O)C=C2)=O
Molecular Formula
C18H12N2O4S
Molecular Weight
352.36
References & Citations
[1]Swain B, et al. New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation. Bioorg Med Chem. 2020 Aug 1;28 (15) :115586.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA XII

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