MGluR2 modulator 5

• Target :

  GluR

• Related Pathways :

  Neuroscience

• Bioactivity :

  MGluR2 modulator5 (Compound 11) is a selective negative allosteric modulator with oral activity, exhibiting an IC50 of 8.9 nM. Pharmacokinetic studies in rats have demonstrated its effective penetration through the blood-brain barrier. This compound is utilized in research related to cognitive and neurological functions in mood disorders, contributing to the field of neurological diseases.

• Smiles :

  O=C1C2=C(C=NN2[C@@H](C)CN1C3=CC=C(C(F)(F)F)C=C3)C=4C=C(C)N=CC4

• Molecular Formula :

  C20H17F3N4O

• Molecular Weight :

  386.37

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1639898-35-3