TRβ agonist 2

• UNSPSC Description:

  TRβ agonist 2 (Compound 1) is a potent agonist of TRβ. TRβ agonist 2 reduces lipid accumulation in HepG2 and promote lipolysis with comparable effects. TRβ agonist 2 is a new potential TRβ-selective thyromimetics[1].

• Target Antigen:

  Thyroid Hormone Receptor

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/trβ-agonist-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(NC1=C(C=C(C=C1)CC2=C(C=C(C=C2C)OCC(O)=O)C)C(C)C)=O

• Molecular Weight:

  369.45

• References & Citations:

  [1]Runfola M, et al. Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis. Eur J Med Chem. 2020 Feb 15;188:112006.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2411099-30-2