TRβ agonist 1

• Description:

  TRβ agonist 1 is a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, with an EC50 value of 21 nM. TRβ agonist 1 can be used for researching dyslipidemia, nonalcoholic steatohepatitis (NASH), and resistance to thyroid hormone (RTH) [1].

• UNSPSC:

  12352005

• Target:

  Thyroid Hormone Receptor

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/trβ-agonist-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C(C2=CC=C(C=C2C(OC)=N1)OC3=C(C=C(C=C3C)C(C4=CC(OC)=CC(F)=C4)=O)C)O)NCC(O)=O

• Molecular Formula:

  C29H25FN2O8

• Molecular Weight:

  548.52

• References & Citations:

  [1]Li Q, et al. Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist. J Med Chem. 2022;65 (10) :7193-7211.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2770681-85-9