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TRβ agonist 1

CAT: 0804-HY-146997-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-146997-01Size:5 mg
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Description
TRβ agonist 1 is a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, with an EC50 value of 21 nM. TRβ agonist 1 can be used for researching dyslipidemia, nonalcoholic steatohepatitis (NASH), and resistance to thyroid hormone (RTH) [1].
CAS Number
2770681-85-9
UNSPSC
12352005
Target
Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/trβ-agonist-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C2=CC=C(C=C2C(OC)=N1)OC3=C(C=C(C=C3C)C(C4=CC(OC)=CC(F)=C4)=O)C)O)NCC(O)=O
Molecular Formula
C29H25FN2O8
Molecular Weight
548.52
References & Citations
[1]Li Q, et al. Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist. J Med Chem. 2022;65 (10) :7193-7211.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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