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TRPA1 agonist-2

CAT: 0804-HY-178492Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178492Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRPA1 agonist-2 (Compound 4B) is an orally active and highly selective TRPA1 channel agonist. TRPA1 agonist-2 triggers calcium influx and stimulates GLP-1 secretion. TRPA1 agonist-2 is promising for research of diabetes, obesity, and related neurodegenerative diseases[1].
UNSPSC
12352101
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Metabolic Disease; Neurological Disease
Smiles
O=C(CC1=CC=CC=C1)N2C[N@@](CC=C[C@H]3O2)[C@@]3([H])C4=CC(C(F)(F)F)=CC=C4
Molecular Formula
C21H19F3N2O2
Molecular Weight
388.38
References & Citations
[1]Comparini LM, et al. Synthesis and biological evaluation of N-O heterobicyclic ring systems derived from 1,2-dihydropyridines as novel TRPA1 activators: implication in GLP-1 release and neuroprotection. Eur J Med Chem. 2025 Dec 15;300:118115.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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